Diuretics: It’s usually not a problem to take NSAIDs if you also take diuretics.Selective serotonin reuptake inhibitors (SSRIs): Bleeding within the digestive system may also be a problem if you take NSAIDs with selective serotonin reuptake inhibitors (SSRIs).Low dose aspirin: Taking NSAIDs with low dose aspirin can increase the risk of developing stomach ulcers.Lithium: Combining NSAIDs with the mood-stabilizing drug lithium can lead to a dangerous buildup of lithium in your body.Taking it with an NSAID can lead to kidney damage. It’s also prescribed to people who’ve had an organ transplant. Cyclosporine: Cyclosporine (Neoral, Sandimmune) is used to treat arthritis or ulcerative colitis (UC).The combination can lead to excessive bleeding. Warfarin: NSAIDs can enhance the effect of warfarin (Coumadin), a medication used to prevent or treat blood clots.Exercise caution if you take the following drugs: Other drug combinations can cause serious side effects, too. Two examples are blood pressure medications and low dose aspirin (when used as a blood thinner). Some drugs become less effective when they interact with NSAIDs. ![]() NSAIDs can interact with other medications. People with cardiovascular disease have an increased risk of developing heart-related issues from taking NSAIDs. The risk of developing these conditions increases with frequent use and higher dosages. They may be less likely to cause stomach irritation than nonspecific NSAIDs. If you develop gastrointestinal issues, a healthcare professional may recommend you switch to a selective COX-2 inhibitor such as celecoxib (Celebrex). You can decrease your likelihood of developing stomach issues by taking NSAIDs with food, milk, or an antacid. The risk of developing stomach issues is higher for people who: If you experience any of the following symptoms, stop using the NSAID immediately and talk with a healthcare professional: Some ulcers can even lead to internal bleeding. In more serious cases, NSAIDs can irritate your stomach lining enough to cause an ulcer. As a result, taking NSAIDs can contribute to minor gastrointestinal problems, including: NSAIDs block COX-1, which helps protect your stomach lining. Your risk for side effects increases the longer you use them.Ĭonsider talking with a healthcare professional before using NSAIDs for an extended period, and do not take different types of NSAIDs simultaneously. ![]() NSAIDs are intended for occasional and short-term use. There are possible side effects and risks, including stomach and heart issues. Just because you can buy some NSAIDs without a prescription doesn’t mean they’re completely harmless. Celecoxib (Celebrex) is currently the only selective COX-2 inhibitor available by prescription in the United States. ![]() Selective COX-2 inhibitors are NSAIDs that block more COX-2 than COX-1. Nonspecific NSAIDs that are available with a prescription in the United States include: Low dose aspirin isn’t typically categorized as an NSAID. Nonspecific NSAIDs that are available over the counter in the United States include: Most NSAIDs are nonspecific, which means that they block both COX-1 and COX-2. Your body produces two types of COX: COX-1 and COX-2.ĬOX-1 protects your stomach lining, while COX-2 causes inflammation. NSAIDs block the enzyme cyclooxygenase (COX) from creating prostaglandins. ![]() Other options for long-term arthritis management include meloxicam (Vivlodex, Mobic), which is taken once a day, and diclofenac (Voltaren), a topical NSAID. This is because it’s easier on your stomach than other NSAIDs. The prescription drug celecoxib (Celebrex) is often prescribed for long-term management of arthritis symptoms. NSAIDs tend to be inexpensive and easily accessible, so they’re often the first medications prescribed to people with arthritis. NSAIDs are especially important for managing the symptoms of arthritis, such as joint pain, inflammation, and stiffness. inflammation and stiffness caused by arthritis and other inflammatory conditions.NSAIDs can be helpful in reducing many types of discomfort, including: Prostaglandins also play a role in controlling your body temperature.īy inhibiting the effects of prostaglandins, NSAIDs help relieve pain and bring down a fever. NSAIDs work by blocking prostaglandins, which sensitize your nerve endings and enhance pain during inflammation.
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